Research Area 3

Effective combination of PCR, antibody tests, and other tests necessary for improving test efficiency and reliability

Objectives: To understand the immune response of the host immune system to SARS-CoV-2 infection, to enable monitoring of the infection situation at home and abroad, to establish reliable standard testing procedures to enable comparison of the effectiveness of infection control measures and prediction and verification of the impact of international human mobility, and to enable the sharing of such data.

  • (3-1)International standardization of testing systems related to infection status, including PCR, antigen and antibody tests. Considering the complexity of the immune system and the inherent host response of SARS-CoV-2, we should standardize the testing system for antibody tests, including tests related to the response of CD4+ T cells and CD8+ T cells to SARS-CoV-2-related epitopes, which will lead to the understanding of the cross-immunity situation.
  • (3-2)International comparison of measurement capability and accuracy. Can an international standard data model be established? Is it possible to supply reference materials by national metrology institutes? Establishment of scientifically based methodologies for precision control. Cooperation with the National Institute of Infectious Diseases and AMED is important and need to be addressed.
  • (3-3)Based on the characteristics of PCR tests, antigen tests, and antibody tests (false-positive and false-negative rates, time required, testing systems, etc.), can we optimize testing systems for various infection situations, thereby contributing to greater efficiency and the formulation of more strategic testing policies?
  • (3-4)Is it possible to perform genetic analysis of the virus from samples from positive PCR testers to determine which virus strains are spreading and monitor new mutations to verify the status of infection and how to treat patients?